Chiral bisoxazoline catalysts

A heterogeneous chiral catalyst comprising a heterogeneous chiral catalyst precursor complexed with a metal species, said heterogeneous chiral catalyst precursor comprising a chiral bisoxazoline group coupled to an inorganic substrate, and said precursor being made by a process comprising coupling a chiral bisoxazoline to a hydrophobic inorganic substrate.

A process for making a heterogeneous chiral catalyst precursor comprising coupling a chiral bisoxazoline to a hydrophobic inorganic substrate.

A process for making a heterogeneous chiral catalyst comprising coupling a chiral bisoxazoline to a hydrophobic inorganic substrate to make a heterogeneous chiral catalyst precursor and treating the heterogeneous chiral catalyst precursor with a metal species.

A heterogeneous chiral catalyst when made by a process comprising coupling a chiral bisoxazoline to a hydrophobic inorganic substrate to make a heterogeneous chiral catalyst precursor and treating the heterogeneous chiral catalyst precursor with a metal species.

A method for catalysing reaction of a starting material to a product comprising exposing the starting material to a heterogeneous chiral catalyst comprising a heterogeneous chiral catalyst precursor complexed with a metal species, said heterogeneous chiral catalyst precursor comprising a chiral bisoxazoline group coupled to an inorganic substrate, said precursor being made by a process comprising coupling a chiral bisoxazoline to a hydrophobic inorganic substrate.

A chiral product when made by a reaction catalysed by a heterogeneous chiral catalyst comprising a heterogeneous chiral catalyst precursor complexed with a metal species, said heterogeneous chiral catalyst precursor comprising a chiral bisoxazoline group coupled to an inorganic substrate, and said precursor being made by a process comprising coupling a chiral bisoxazoline to a hydrophobic inorganic substrate.

A heterogenous chiral catalyst precursor comprising a chiral bisoxazoline group coupled to an inorganic substrate, whereby said precursor is capable of complexing with Cu(I) to form a heterogeneous chiral catalyst, said catalyst being capable of catalysing a cyclopropanation reaction of an olefin with an azo compound with greater than 50% yield.

A heterogenous chiral catalyst precursor comprising a chiral bisoxazoline group coupled to an inorganic substrate, whereby said precursor is capable of complexing with Cu(I) to form a heterogeneous chiral catalyst, said catalyst being capable of catalysing a cyclopropanation reaction of an olefin with an azo compound with greater than 60% enantioselectivity.

A heterogeneous chiral catalyst comprising a heterogeneous chiral catalyst precursor complexed with a metal species, said heterogeneous chiral catalyst precursor comprising a chiral bisoxazoline group coupled to an inorganic substrate and said catalyst being capable of catalysing a cyclopropanation reaction of an olefin with an azo compound with greater than 50% yield.

A heterogeneous chiral catalyst comprising a heterogeneous chiral catalyst precursor complexed with a metal species, said heterogeneous chiral catalyst precursor comprising a chiral bisoxazoline group coupled to an inorganic substrate and said catalyst being capable of catalysing a cyclopropanation reaction of an olefin with an azo compound with greater than 60% enantioselectivity.