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US 2011/0034677 A1Published application
Recurrent gene fusions in prostate cancer
AssigneesThe Regents of the University of Michigan, The Brigham and Women's Hospital, Inc.
InventorsScott Tomlins, Daniel Rhodes, Arul Chinnaiyan, Rohit Mehra, Mark A. Rubin, Xiao-Wei Sun, Sven Perner, Charles Lee, Francesca Demichelis
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Abstract
Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.
Claims1
A composition comprising at least one of the following:
- (a) an oligonucleotide probe comprising a sequence that hybridizes to a junction of a chimeric genomic DNA or chimer mRNA in which a 5′ portion of the chimeric genomic DNA or chimeric mRNA is from a transcriptional regulatory region of an androgen regulated gene and a 3′ portion of the chimeric genomic DNA or chimeric mRNA is from an ETS family member gene;
- (b) a first oligonucleotide probe comprising a sequence that hybridizes to a 5′ portion of a chimeric genomic DNA or chimeric mRNA from a transcriptional regulatory region of an androgen regulated gene and a second oligonucleotide probe comprising a sequence that hybridizes to a 3′ portion of the chimeric genomic DNA or chimeric mRNA from an ETS family member gene;
- (c) a first amplification oligonucleotide comprising a sequence that hybridizes to a 5′ portion of a chimeric genomic DNA or chimeric mRNA from a transcriptional regulatory region of an androgen regulated gene and a second amplification oligonucleotide comprising a sequence that hybridizes to a 3′ portion of the chimeric genomic DNA or chimeric mRNA from an ETS family member gene;
- (d) an antibody to an amino-terminally truncated ETS family member protein encoded by a fusion of a transcriptional regulatory region of an androgen regulated gene to an ETS family member gene;
- or,
- (e) an antibody to a chimeric protein having an amino-terminal portion encoded by a transcriptional regulatory region of an androgen regulated gene and a carboxy-terminal portion encoded by an ETS family member gene.
3 more elements
Dependencies are inferred from the claim text.