Back to results
US 2011/0034643 A1Published application
Thiol-Selective Water-Soluble Polymer Derivatives
AssigneeNektar Therapeutics
InventorsAntoni Kozlowski, Remy F. Gross, III, Samuel P. McManus
Life of this patent
Estimating the term…
Abstract
The present invention provides water-soluble, polymer derivatives having a thiol-selective terminus suitable for selective coupling to thiol groups, such as those contained in the cysteine residues of proteins, as well as methods for preparing the water-soluble, polymer derivatives having a thiol-selective terminus.
Claims16
A method for preparing a thiol-selective derivative of a water-soluble polymer, said method comprising the steps of:
- (i) providing an electrophilically-activated polymer, POLY-L0,1-E,
- wherein:
- POLY is a water-soluble polymer segment,
- L is an optional linker, and
- E is an electrophile selected from the group consisting of carboxylic acid and an activated carboxylic acid derivative, and
- (ii) reacting said POLY-L0,1-E with NU-Y—S, wherein NU-Y—S is N-(2-amino-ethyl)-3-maleimido-propionamide,
- to thereby form
4 more elements
A thiol-selective derivative of a water-soluble polymer, encompassed by the following structure:
- wherein:
- POLY is a water-soluble polymer segment;
- and
- L is an optional linker.
1 more element
Dependencies are inferred from the claim text.