Cell Repair And Regeneration By Suramin And Related Polysulfonated Naphthylureas
OwnerRick G. Schnellmanninventor
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Abstract
Disclosed herein are compositions and methods for promoting the repair and regeneration of injured tissues, such as injuries resulting from ischemic damage. Also disclosed are compositions and methods for accelerating wound healing in diabetic and elderly patients and inhibiting allograft failure.
Claims39
A method of accelerating wound healing in a subject, comprising administering to a subject in need of wound healing a composition comprising a therapeutically effective amount of suramin or an analogue or derivative thereof.
A method of inhibiting allograft failure in a graft recipient comprising administering to recipient of the graft a composition comprising a therapeutically effective amount of suramin or an analogue or derivative thereof.
A method of promoting tissue repair and/or wound healing in a subject, comprising administering to a subject in need of tissue repair and/or regeneration a composition comprising a therapeutically effective amount of a compound comprising the structure:
- wherein R1a and R1b are, independently, hydrogen, hydroxyl, alkyl, aryl, alkoxy, carboxyl, ester, ester, amino, or amide, and
- wherein R2a and R2b are, independently, hydrogen, hydroxyl, alkyl, aryl, acyl, alkoxy, carboxyl, ester, ester, amino, amide, or halide.
Dependencies are inferred from the claim text.