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US 2011/0034553 A1Published application
Novel conjugates for treating neurodegenerative diseases and disorders
AssigneeRamot at Tel-Aviv University Ltd.
InventorsGideon Stein, Abraham Nudelman, Ada Rephaeli, Irit Gil-Ad, Abraham Weizman
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Abstract
A conjugate comprising L-DOPA covalently linked to at least one y-aminobutyric acid (GABA) moiety, an ester and/or an addition salt thereof are disclosed, as well as uses thereof for treating a neurodegenerative disease or disorder.
Claims35
A compound having the general formula I:
- wherein:
- R1-R3 are each independently selected from the group consisting of hydrogen, 4-amino-butyryl (GABA) and butyryl;
- and
- R4 is selected from the group consisting of hydrogen, alkyl, butyryloxyalkyl and 4-amino butyryloxyalkyl,
- such that at least one of R1-R3 being said 4-amino-butyryl and/or R4 is said 4-aminobutyryloxyalkyl, and a pharmaceutically acceptable acid addition salt thereof.
2 more elements
-35. (canceled)
Dependencies are inferred from the claim text.