Compositions and methods modulating mg29 for the treatment of diabetes
AssigneeUniversity of Medicine and Dentistry of New Jersey
InventorsJIANJIE MA, NOAH WEISLEDER, HUA ZHU, PEIHUI LIN
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Abstract
Disclosed herein are compositions and methods for treatment of muscle dysfunction, including diabetes. In addition, the invention relates to therapeutic compositions comprising nucleotides and/or polypeptides of the invention in combination with a pharmaceutically acceptable carrier, wherein the composition facilitates the treatment of skeletal muscle disorders. Moreover, the invention relates to the treatment and/or prevention of pathological conditions associated with altered intracellular Ca2+ regulation and disrupted membrane structure that occurs when the expression levels of MG29 are reduced.
Claims20
A method for modulating glucose uptake in a cell, comprising administering to a muscle cell a composition comprising an effective amount of an agent that modulates the expression of an MG29 gene, or modulates the activity of an MG29 polypeptide or both, wherein the modulation of MG29 results in the modulation of glucose uptake in the cell.
A method of treating diabetes comprising administering to an individual a composition comprising an effective amount of an agent that performs at least one of:
- increasing the expression of an MG29 gene, increasing the activity of an MG29 polypeptide, or a combination of both, wherein the agent is effective for the treatment of diabetes.
A method for screening for agents effective for modulating the glucose uptake by skeletal muscle comprising providing a cell or tissue;
- measuring for the amount of at least one of endogenous MG29 activity, protein level, or gene expression to establish a control value;
- contacting a test agent to the cell or tissue;
- measuring or detecting the activity of at least one of MG29, amount of MG29 protein, or amount of MG29 gene expression to establish a test value;
- and comparing the control value to the test value, wherein an observed change between the test and control values indicates an agent capable of modulating glucose uptake by skeletal muscle.
Dependencies are inferred from the claim text.