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US 2011/0034527 A1Published application
Novel 2-amino benzimidazole derivatives and their use as modulators of small-conductance calcium-activated potassium channels
OwnerUlrik Svane SØRENSEN, Lene Teuber +5inventors
InventorsUlrik Svane SØRENSEN, Lene Teuber, Dan Peters, Dorte Strøbæk, Tina Holm Johansen, Karin Sandager Nielsen, Palle Christophersen
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Abstract
This invention relates to novel 2-amino benzimidazole derivatives useful as modulators of small-conductance calcium-activated potassium channels (SK channels). In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
Claims11
A 2-amino benzimidazole derivative of Formula Ia:
- or any of its isomers or any mixture of its isomers,
- or a pharmaceutically acceptable salt thereof, wherein
- m is 0, 1 or 2;
- n is 0, 1 or 2;
- R′ is hydrogen or alkyl;
- R1 and R2 independent of each other represent a phenyl group, which phenyl group is optionally substituted with one or more substituents independently selected from the group consisting of:
- halo, trifluoromethyl, trifluoromethoxy, cyano, alkyl, RaRbN— and RaRbN-alkyl;
- wherein Ra and Rb independent of each other are hydrogen or alkyl;
- and
- R4, R5, R6 and R7 independent of each other are selected from the group consisting of:
- hydrogen, halo, trifluoromethyl, trifluoromethoxy, cyano, alkyl and alkoxy.
8 more elements
Dependencies are inferred from the claim text.