Inhibitors of P38 Map Kinase

A compound of formula (I):

• wherein:
• G is —N═ or —CH═
• D is an optionally substituted divalent mono- or bi-cyclic aryl or heteroaryl radical having 5-13 ring members;
• R6 is hydrogen or optionally substituted C1-C3 alkyl;
• P represents hydrogen and U represents a radical of formula (IA);
• or U represents hydrogen and P represents a radical of formula (IA);
• -A-(CH2)z—X1-L1-Y—NH—CR1R2R3 (IA)
• wherein
• A represents an optionally substituted divalent mono- or bicyclic carbocyclic or heterocyclic radical having 5-13 ring members;
• z is 0 or 1;
• Y is a bond, —C(═O)—, —S(═O)2—, —C(═O)NR7—, —C(═S)—NR7, —C(═NH)NR7 or —S(═O)2NR3— wherein R7 is hydrogen or optionally substituted C1-C6 alkyl;
• L1 is a divalent radical of formula -(Alk1)m(Q)n(Alk2)p- wherein
• m, n and p are independently 0 or 1,
• Q is (i) an optionally substituted divalent mono- or bicyclic carbocyclic or heterocyclic radical having 5-13 ring members, or (ii), in the case where both m and p are 0, a divalent radical of formula —X2-Q1- or -Q1-X2— wherein X2 is —O—, S— or NRA— wherein RA is hydrogen or optionally substituted C1-C3 alkyl, and Q1 is an optionally substituted divalent mono- or bicyclic carbocyclic or heterocyclic radical having 5-13 ring members,
• Alk1 and Alk2 independently represent optionally substituted divalent C3-C7 cycloalkyl radicals, or optionally substituted straight or branched, C1-C6 alkylene, C2-C6 alkenylene, or C2-C6 alkynylene radicals which may optionally contain or terminate in an ether (—O—), thioether (—S—) or amino (—NRA—) link wherein RA is hydrogen or optionally substituted C1-C3 alkyl;
• and
• X1 represents a bond;
• —C(═O);
• or —S(═O)2—;
• —NR4C(═O)—, —C(═O)NR4—, —NR4C(═O)NR5—, —NR4S(═O)2—, or —S(═O)2NR4— wherein R4 and R5 are independently hydrogen or optionally substituted C1-C6 alkyl.
• R1 is a carboxylic acid group (—COOH), or an ester group which is hydrolysable by one or more intracellular esterase enzymes to a carboxylic acid group;
• and
• R2 and R3 are selected from the side chains of a natural or non-natural alpha-amino acid, provided that neither R2 or R3 is hydrogen.