Spiroindolines as modulators of chemokine receptors

A compound of the following formula:

• or a pharmaceutically acceptable salt thereof or an enantiomer thereof;
• where each R1 is independently halo, CF3, C1-C4-alkyl, C1-C4-alkoxy, OCF3, CN, C1-C6-alkyl-C(O)—NH—, C1-C6-alkyl-NH—C(O)—, —CH2—N(R7)2, —CH2—O—R8, C1-C4—S(O)r—, COOH, or heteroaryl;
• R2 is H, C1-C4-alkyl, —CH2C(O)OR9, or CH2C(O)N(R9)2;
• each R3 is independently C1-C6-alkyl or hydroxy-C1-C6-alkyl;
• each R4 is independently OH, F, Cl, CN, C1-C4-alkyl, hydroxy-C1-C4-alkyl, or C1-C4-alkoxy;
• Y is —NH— or
• R5 is H, OH, F, Cl, CN, CF3, hydroxy-C1-C6-alkyl, or C1-C6-alkoxy;
• each R6 is independently halo, CF3, C1-C4-alkoxy, OCF3, benzyloxy, or CN;
• each R7 is independently H, C1-C4-alkyl, or, together with the nitrogen atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group;
• R8 is H, C1-C6-alkyl, benzyl, or phenyl;
• each R9 is independently H, C1-C6-alkyl, or benzyl;
• each R10 is independently OH, F, Cl, CN, hydroxy-C1-C4-alkyl, or C1-C4-alkoxy;
• n is 0, 1, or 2;
• m is 0, 1, 2, or 3;
• p is 0, 1, or 2:
• q is 0, 1, or 2;
• r is 0, 1, or 2;
• and
• s is 0, 1, or 2.