Dosing regimens for the treatment of cancer
OwnerKaren J. Mcgovern, Christine S. Pien +1inventors
InventorsKaren J. Mcgovern, Christine S. Pien, James L. Wright
Life of this patent
Estimating the term…
Abstract
The invention relates to a method of treating cancer. The method includes administering systemically a therapeutically effective amount of a small molecule hedgehog pathway inhibitor, such that the concentration of the inhibitor in the blood does not vary by more than about ±30% from the average concentration, and such that the concentration remains at or below the maximum tolerated dose of the inhibitor for a time period of at least about one day.
Claims29
A method of treating cancer in a human in need of such treatment, comprising administering systemically to said human a therapeutically effective amount of a small molecule hedgehog pathway inhibitor, wherein the concentration of said inhibitor in the blood of said human does not vary by more than about ±30% from the average concentration of said inhibitor in the blood of said human, and said concentration remains at or below the maximum tolerated dose of said inhibitor for a time period of at least about one day.
A method of treating cancer in a human in need of such treatment, comprising administering systemically to said human a therapeutically effective amount of a small molecule hedgehog pathway inhibitor, wherein said inhibitor is present in the blood of said human at a concentration that is maintained above a threshold concentration, and remains at or below the maximum tolerated dose of said inhibitor in a human for a time period of at least about one day.
Dependencies are inferred from the claim text.