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US 2011/0034485 A1Published application
Nitrone compounds, process of preparation thereof, and use thereof in medicament manufacture
AssigneeJinan University
InventorsYuqiang Wang, Jie Jiang, Pei Yu, Yewei Sun, Linda Wang, Zaijun Zhang
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Abstract
The present invention provides novel nitrones, their preparation and use. The novel compounds have the following formula: I The compounds of the present invention have strong antioxidative activity, and are thrombolytic. These compounds can be used to treat and/or prevent diseases caused by overproduction of free radicals and/or formation of thrombus.
Claims18
A compound of the following formula (I) or a pharmaceutically acceptable salt thereof:
- wherein:
- R1, R2, and R3 are independently selected from the group consisting of H, OH, NH2, COOH, alkyl, aryl, heteroaryl, ester, amide, and carbamate, wherein the R1, R2, and R3 can be the same or different with the proviso that all R1, R2, and R3 cannot be H at the same time;
- and
- X and Y are independently C, N, O or S, but are not C at the same time.
1 more element
Dependencies are inferred from the claim text.