Oral Pharmaceutical Compositions in a Solid Dispersion Comprising Preferably Posaconazole and HPMCAs
AssigneeSchering-Plough Corporation
InventorsLarry Yun Fang, Jiansheng Wan, David Harris
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Abstract
The present invention provides a solid molecularly dispersed composition comprising a poorly water soluble and weakly basic azole antifungal compound and a pH sensitive polymer, pharmaceutical compositions, comprising the solid molecularly dispersed composition of the invention and methods of treating and/or preventing a fungal infection in a patient in need thereof comprising orally administering a pharmaceutical composition comprising a composition of the invention to a patient in need thereof. Preferably the antifungal, compound is posaconazole, and the pH sensitive polymer is HPMCAS.
Claims5
A composition comprising a weakly basic and poorly-aqueous soluble azole molecularly dispersed in at least one pH sensitive polymer prepared by evaporating the solvent from a solution comprising the azole and said at least one pH sensitive polymer.
A composition comprising posaconazole molecularly dispersed in hypromellose acetate succinate prepared by evaporating the solvent from a solution comprising posaconazole and the hypermellose acetate succinate polymer.
A method for the treatment or prevention of a fungal infection, the method comprising administering to a patient in need thereof an oral pharmaceutical composition comprising a solid molecular dispersion prepared by a spray-drying technique, wherein the solid molecular dispersion comprises:
- (a) posaconazole;
- and
- (b) hypromellose acetate succinate (HPMCAS).
Dependencies are inferred from the claim text.