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US 2011/0034476 A1Published application
Genetic polymorphisms and infertility
AssigneeThe University of North Carolina at Chapel Hill
InventorsSteven H. Zeisel, Amy Johnson
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AssigneeThe University of North Carolina at Chapel Hill
InventorsSteven H. Zeisel, Amy Johnson
Estimating the term…
Methods of screening for a cause of low sperm motility and/or for mitochondrial impairment in subjects are provided, comprising determining a genotype of the subject with respect to at least one choline metabolism gene and comparing the genotype of the subject with at least one reference choline metabolism genotype associated with low sperm motility and/or impaired mitochondrial function, wherein a similarity between the subject and reference genotypes indicates a cause of low sperm motility and/or impaired mitochondrial function in the subject. In another aspect, methods for treating subjects having low sperm motility and/or impaired mitochondrial function are provided, comprising administering to the subject an effective amount of a choline metabolism supplement composition to at least partially ameliorate the low sperm motility and/or impaired mitochondrial function.
A method of screening for a cause of low sperm motility in a male subject, comprising:
A method of treating male infertility due to low sperm motility, comprising, administering to the subject an effective amount of a choline metabolism supplement composition, wherein the choline metabolism supplement composition at least partially ameliorates the low sperm motility.
A method of screening for defects in mitochondrial function, comprising:
A method of treating a subject having an impairment in mitochondrial function, comprising, administering to the subject an effective amount of a choline metabolism supplement composition, wherein the choline metabolism supplement composition at least partially ameliorates the impairment in mitochondrial function.
A method of identifying polymorphisms indicative of low sperm motility and/or impaired mitochondrial function, the method comprising:
Dependencies are inferred from the claim text.