Novel Compounds for Treatment of Cancer and Disorders Associated With Angiogenesis Function
AssigneeUniversity of Southern California
InventorsNouri NEAMATI, Antonio GAROFALO
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Abstract
Novel compounds for treatment of cancer and disorders associated with angiogenesis function. Also disclosed are a method of preparing the compounds, pharmaceutical compositions and packaged products containing the compounds, a method of using these molecules to treat cancer (e.g., leukemia, non-small cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, breast cancer, renal cancer, and prostate cancer) and disorders associated with angiogenesis function (e.g., age-related macular degeneration, macular dystrophy, and diabetes), a method of monitoring the treatment, a method of profiling gene expression, and a method of modulating cell growth, cell cycle, apoptosis, or gene expression.
Claims7
A composition comprising a compound of formula
- wherein R1is F, R2 is H, and R3 is
- wherein R1 is H, R2 is F, and R3 is
- or
- wherein R1 is F, R2 is H, and R3 is
- or a pharmaceutically acceptable salt, solvate, or hydrate thereof.
A method of preparing a compound according to the following scheme (Scheme 7):
- wherein R1 is F, R2 is H, and R3 is
- wherein R1 is H, R2 is F, and R3 is
- wherein R1 is F, R2 is H, and R3 is
- or
- wherein R1 is F, R2 is H, and R3 is
A method of modulating cell growth, cell cycle, or apoptosis, comprising contacting a cell with SC161′, thereby inhibiting cell growth, arresting cell cycle, or inducing apoptosis.
A method of treating a subject, comprising administering to a subject in need thereof an effective amount of SC160′, 161′, or 166′.
Dependencies are inferred from the claim text.