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US 2011/0034467 A1Published application
Dihydro-pyrrolopyridine-, dihydro-pyrrolopyridazine- and dihydro-pyrrolopyrimidine-derivatives and use thereof
OwnerSusanne Röhrig, Mario Jeske +2inventors
InventorsSusanne Röhrig, Mario Jeske, Elisabeth Perzborn, Mark Jean Gnoth
Life of this patent
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Abstract
The invention relates to novel dihydro-pyrrolopyridine, dihydro-pyrrolopyridazine and dihydro-pyrrolopyrimidine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of thromboembolic disorders.
Claims14
Compound of the formula
- in which
- n represents the number 1, 2 or 3,
- m represents the number 0, 1 or 2,
- and the (CH2)m group is attached in the 1- or 2-position to the phenyl ring,
- R1 represents hydrogen, cyano, hydroxy, C1-C4-alkyl, C1-C4-alkylcarbonyl, C3-C6-cycloalkylcarbonyl, phenylcarbonyl, 4- to 7-branched heterocyclylcarbonyl or 5- or 6-branched heteroarylcarbonyl,
- R2 represents hydrogen, fluorine, chlorine, cyano, hydroxy, amino, trifluoromethyl, trifluoromethoxy, C1-C4-alkyl, C1-C4-alkoxy, C1-C4-alkoxymethyl, C1-C4-alkylamino, C3-C6-cycloalkyl, aminocarbonyl, C1-C4-alkoxycarbonyl or C1-C4-alkylaminocarbonyl,
- R3 represents hydrogen, fluorine, chlorine, cyano, hydroxy, amino, trifluoromethyl, trifluoromethoxy, C1-C4-alkyl, C1-C4-alkoxy, C1-C4-alkoxymethyl, C1-C4-alkylamino, C3-C6-cycloalkyl, aminocarbonyl, C1-C4-alkoxycarbonyl or C1-C4-alkylaminocarbonyl,
- R4 and R5 represent hydrogen,
- and
- R6 and R7 together with the carbon atom to which they are attached form a carbonyl group,
- or
- R4 and R5 together with the carbon atom to which they are attached form a carbonyl group,
- and
- R6 and R7 represent hydrogen,
- or
- R4 and R5 together with the carbon atom to which they are attached form a carbonyl group,
- and
- R6 and R7 together with the carbon atom to which they are attached form a carbonyl group,
- R8, R9, R10 and R11 together represent a group of the formula
- in which
- R12 represents phenyl, pyridyl, pyrazinyl, pyrimidinyl, pyridazinyl or thienyl, where phenyl, pyridyl, pyrazinyl, pyrimidinyl and pyridazinyl are substituted by a substituent R15 and/or a substituent R16 or by two different substituents R15 or by two different substituents R16,
- where
- R15 is attached to a carbon atom which is not adjacent to a nitrogen atom in the ring and represents hydrogen, fluorine, chlorine, cyano, ethynyl, C1-C4-alkyl, C1-C4-alkoxy or C3-C6-cycloalkyl,
- R16 is attached to a carbon atom which is adjacent to a nitrogen atom in the ring and represents hydrogen, amino, C1-C4-alkyl, C1-C4-alkylamino or C3-C6-cycloalkyl,
- and
- where thienyl is substituted by a substituent R13 and a substituent R14,
- where
- R17 is attached to a carbon atom which is adjacent to the sulphur atom in the ring and represents hydrogen, fluorine, chlorine, cyano, ethynyl, C1-C4-alkyl, C1-C4-alkoxy or C3-C6-cycloalkyl,
- R18 represents hydrogen, fluorine, chlorine, amino, C1-C4-alkyl, C1-C4-alkylamino or C3-C6-cycloalkyl,
- R13 represents hydrogen, amino, ethynyl, C1-C4-alkyl, C1-C4-alkylamino or C3-C6-cycloalkyl, or
- R14 represents hydrogen, fluorine, chlorine, cyano, hydroxy, amino, trifluoromethyl, trifluoromethoxy, C1-C4-alkyl, C1-C4-alkoxy, C1-C4-alkylamino, C3-C6-cycloalkyl, aminocarbonyl, C1-C4-alkoxycarbonyl or C1-C4-alkylamino carbonyl,
- or one of its salts, its solvates or the solvates of its salts.
29 more elements
(canceled)
(canceled)
Dependencies are inferred from the claim text.