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US 2011/0034453 A1Published application
Aminoacyl Prodrug Derivatives and Medicaments for the Treatment of Thromboembolitic Disorders
AssigneeBayer Helthcare AG
InventorsHans-Georg Lerchen, Ursula Krenz, Karl-Heinz Schlemmer, Elisabeth Perzborn, Joerg Keldenich
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Abstract
The present application relates to prodrug derivatives of 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of thromboembolic disorders.
Claims12
A compound of formula (I)
- in which
- R1 is hydrogen or (C1-C4)-alkyl which may be substituted by hydroxy or (C1-C4)-alkoxy,
- R2 is hydrogen or (C1-C4)-alkyl,
- and
- L is a (C1-C4)-alkanediyl group in which one CH2 group may be replaced by an O atom, or is a group of the formula
- in which
- * means the point of linkage to the N atom,
- R3 is the side group of a natural α-amino acid or its homologues or isomers,
- or
- R3 is linked to R1 and the two together form a (CH2)3 or (CH2)4 group,
- R4 is hydrogen or methyl,
- R5 is (C1-C4)-alkyl,
- and
- R6 is hydrogen or (C1-C4)-alkyl,
- and the salts, solvates and solvates of the salts thereof.
12 more elements
Dependencies are inferred from the claim text.