Selected cgrp antagonists, processes for preparing them and their use as pharmaceutical compositions

A compound of the formula I

• wherein
• R1 denotes a group selected from
• wherein
• R1.1 denotes H or H3C—O,
• R2 denotes a group selected from
• R3 denotes a group of general formula II
• wherein
• X denotes N or C,
• R3.1 denotes H, C1-3-alkyl or R3.1.1—O—C(O),
• R3.1.1 denotes H, C1-6-alkyl, H2N—C2-4-alkylene, (C1-3-alkyl)-NH—C2-4-alkylene, (C1-3-alkyl)2N—C2-4-alkylene, H2N—C(O)—C1-3-alkylene, (C1-3-alkyl)-NH—C(O)—C1-3-alkylene, (C1-3-alkyl)2N—C(O)—C1-3-alkylene or R3.1.1.1—C2-4-alkylene,
• R3.1.1.1 denotes a group selected from
• R3.2 denotes a pair of free electrons, if X=N, or
• R3.2 denotes H, C1-3-alkyl or R3.2.1—O—C(O), if X=C,
• R3.2.2 denotes H, C1-6-alkyl, H2N—C2-4-alkylene, (C1-3-alkyl)-NH—C2-4-alkylene, (C1-3-alkyl)2N—C2-4-alkylene, H2N—C(O)—C1-3-alkylene, (C1-3-alkyl)-NH—C(O)—C1-3-alkylene, (C1-3-alkyl)2N—C(O)—C1-3-alkylene or R3.2.1.1—C2-4-alkylene,
• R3.2.1.1 denotes a group selected from
• R4 denotes a group of general formulae III
• wherein
• Y denotes C and
• R4.1 denotes H or C1-3-alkyl, or
• Y denotes N and
• R4.1 denotes a pair of free electrons,
• with the proviso that X and Y do not simultaneously represent N,
• R4.2 denotes H, C1-3-alkyl or R4.2.1—O—C(O),
• R4.2.1 denotes H, C1-6-alkyl, H2N—C2-4-alkylene, (C1-3-alkyl)-NH—C2-4-alkylene, (C1-3-alkyl)2N—C2-4-alkylene, H2N—C(O)—C1-3-alkylene, (C1-3-alkyl)-NH—C(O)—C1-3-alkylene, (C1-3-alkyl)2N—C(O)—C1-3-alkylene or R4.2.1.1—C2-4-alkylene,
• R4.2.1.1 denotes a group selected from
• and
• R4.3 denotes H, C1-6-alkyl, H2N—C2-4-alkylene, (C1-3-alkyl)-NH—C2-4-alkylene, (C1-3-alkyl)2N—C2-4-alkylene, H2N—C(O)—C1-3-alkylene, (C1-3-alkyl)-NH—C(O)—C1-3-alkylene, (C1-3-alkyl)2N—C(O)—C1-3-alkylene or R4.3.1—C2-4-alkylene- and
• R4.3.1 denotes a group selected from
• R5.1 denotes H, C1-3-alkyl, R5.1.1—O—C(O), R5.1.1—O—C(O)—C1-3-alkylene-NH, R5.1.1—O—C(O)—C1-3-alkylene-N(C1-3-alkyl), R5.1.1—O—C(O)—C1-3-alkylene-O, R5.1.1—O—C(O)—C1-3-alkylene, R5.1.1—O—C(O)—C(O), R5.1.1—O—C(O)—C(O)—O, R5.1.1—O—C(O)—C1-3-alkylene-C(O) or R5.1.1—O—C(O)—C1-3-alkylene-C(O)—O,
• R5.1.1 denotes H, C1-8-alkyl, phenyl, indanyl, pyridyl-C1-3-alkylene, HO—C2-4-alkylene, C1-6-alkyl-O—C2-4-alkylene, H2N—C2-4-alkylene, (C1-6-alkyl)-NH—C2-4-alkylene, (C1-6-alkyl)2N—C2-4-alkylene, H2N—C(O)—C1-3-alkylene, (C1-6-alkyl)-NH—C(O)—C1-3-alkylene, (C1-6-alkyl)2N—C(O)—C1-3-alkylene, C1-6-alkyl-C(O)—O—C1-3-alkylene, C1-6-alkyl-O—C(O)—O—C1-3-alkylene, R5.1.1.1—C(O)—C1-3-alkylene or R5.1.1.2—C2-4-alkylene,
• R5.1.1.1 denotes a group selected from
• R5.1.1.2 denotes a group selected from
• R5.2 denotes H, C1-3-alkyl, R5.2.1—O—C(O)—C1-3-alkylene-NH, R5.2.1—O—C(O)—C1-3-alkylene-O, R5.2.1—O—C(O)—C1-3-alkylene, R5.2.1—O—C(O)—C(O) or R5.2.1—O—C(O)—C1-3-alkylene-C(O),
• R5.2.1 denotes H, C1-8-alkyl, phenyl, indanyl, pyridyl-C1-3-alkylene, HO—C2-4-alkylene, C1-6-alkyl-O—C2-4-alkylene, C1-6-alkyl-O—C2-4-alkylene-O—C2-4-alkylene, H2N—C2-4-alkylene, (C1-6-alkyl)-NH—C2-4-alkylene, (C1-6-alkyl)2N—C2-4-alkylene, H2N—C(O)—C1-3-alkylene, (C1-6-alkyl)-NH—C(O)—C1-3-alkylene, (C1-6-alkyl)2N—C(O)—C1-3-alkylene, C1-6-alkyl-C(O)—O—C1-3-alkylene, C1-6-alkyl-O—C(O)—O—C1-3-alkylene, R5.2.1.1—C(O)—C1-3-alkylene or R5.2.1.2—C2-4-alkylene,
• R5.2.1.1 denotes a group selected from
• and
• R5.2.1.2 denotes a group selected from
• or
• R5.2.1 denotes a group of formula
• with the proviso that at least one of the groups R3.1, R3.2, R4.2, R5.1 or R5.2 denotes a group other than H or C1-3-alkyl,
• or a tautomer or salt thereof.