Pyrimidine, pyridine and triazine derivatives as maxi-k channel openers

A compound of formula (A):

• wherein ring A is an aromatic ring or a heteroaromatic ring;
• R1 is independently a halogen, cyano, an alkylthio, a cycloalkyl, an alkanoyl, an amino optionally substituted by alkyl(s), an alkylsulfonyl, an alkoxy optionally substituted by one to three substituent(s) independently selected from a halogen, an alkoxy and hydroxy, or an alkyl optionally substituted by one to three substituent(s) independently selected from a halogen, an alkoxy and hydroxy;
• n is 0, 1, 2, 3 or 4;
• Each of X1, X2 and X3 is independently CR2 or nitrogen, provided that at least one of X1, X2 and X3 is nitrogen;
• R2 is independently hydrogen, a halogen, an alkoxy optionally substituted by one to three substituent(s) independently selected from a halogen, an alkoxy and hydroxy, or an alkyl optionally substituted by one or more substituent(s) independently selected from halogen, an alkoxy and hydroxy;
• Y is carboxy, tetrazolyl or an alkoxycarbonyl;
• D is a group of formula:
• R3 is hydrogen or an alkyl optionally substituted by one or more substituent(s) independently selected from an alkoxy and a heteroaryl;
• Each of R4, R5, R6, R7, R8 and R9 is independently hydrogen, or an alkyl, or two of R3, R4, R5, R6, R7, R8 and R9, taken together with the atom(s) to which they are bonded, may form a carbocyclic ring optionally substituted by one or more alkyl(s) or a heterocyclic ring optionally substituted by one or more alkyl(s);
• G is —NR10R11, —OR14, a phenyl optionally substituted by one or more R15(s) or a group of formula:
• R10 is an alkyl optionally substituted by one or more substituent(s) independently selected from an alkoxy, hydroxy, and a group of formula:
• or a cycloalkyl optionally substituted by one or more R12(s);
• R11 is hydrogen, or an alkyl optionally substituted by one to three substituent(s) independently selected from an alkoxy and hydroxy;
• R12 is independently a halogen, cyano, an alkylthio, a cycloalkyl, an alkanoyl, an amino optionally substituted by alkyl(s), an alkylsulfonyl, an alkoxy optionally substituted by one to three substituent(s) independently selected from a halogen, an alkoxy and hydroxy, or an alkyl optionally substituted by one to three substituent(s) independently selected from a halogen, an alkoxy and hydroxy;
• R13 is independently hydroxy, an alkoxy optionally substituted by one to three substituent(s) independently selected from a halogen, an alkoxy, a cycloalkyl and hydroxy, an alkylsulfonyl, oxo, a halogen, cyano, an aryl, a heteroary, an aryloxy, a heteroaryloxy, an alkoxycarbonyl or an alkyl optionally substituted by one to three substituent(s) independently selected from a halogen, hydroxy, and an optionally substituted alkoxy;
• R14 is an alkyl substituted by a group of formula
• or a group of formula
• Ring B1 is a carbocyclic ring, a heterocyclic ring, an aromatic ring or a heteroaromatic ring;
• Ring B2 is a nitrogen containing heterocyclic ring;
• Ring B5 is a carbocyclic ring, a heterocyclic ring, an aromatic ring or a heteroaromatic ring;
• R15 is independently a halogen, cyano, an alkylthio, a cycloalkyl, a cycloalkyloxy, an alkanoyl, an amino optionally substituted by alkyl(s), an alkylsulfonyl, an alkoxy optionally substituted by one to three substituent(s) independently selected from a halogen, an alkoxy, a cycloalkyl and hydroxy, or an alkyl optionally substituted by one to three substituent(s) independently selected from a halogen, an alkoxy and hydroxy;
• R16 is independently a halogen, cyano, an alkylthio, a cycloalkyl, an alkanoyl, an amino optionally substituted by alkyl(s), an alkylsulfonyl, an alkoxy optionally substituted by one to three substituent(s) independently selected from a halogen, an alkoxy and hydroxy, or an alkyl optionally substituted by one to three substituent(s) independently selected from a halogen, an alkoxy and hydroxy;
• m is 0, 1, 2 or 3;
• and
• r is 0, 1, 2 or 3,
• provided that when D is a group of formula:
• G is not a group of formula:
• wherein R13a is an aryl or a heteroaryl,
• when G is phenyl optionally substituted by one or more R15, Ring A is an aromatic ring;
• and when G is phenyl optionally substituted by one R15, D is a group of formula:
• wherein two of R4a, R5a, R6a and R7a, taken together with the atoms to which they are bonded, form a carbocyclic ring optionally substituted by one or more alkyl(s) or a heterocyclic ring optionally substituted by one or more alkyl(s),
• or a pharmaceutically acceptable salt thereof.