Method of Preventing Renal Disease and Treating Symptoms Thereof
AssigneeWisconsin Alumni Research Foundation
InventorsHector F. DeLuca, Margaret Clagett-Dame, Lori Plum
Life of this patent
Estimating the term…
Abstract
The invention relates to novel methods of using 2-methylene-19-nor-20(S)-1,25-dihydroxyvitamin D3 to prevent renal disease, particularly Lupus nephritis, in a subject at risk of developing renal disease. Methods of preventing symptoms of renal disease, such as proteinuria, splenomegaly or glomerular damage are also provided. Methods of treating symptoms of renal disease, including proteinuria and splenomegaly, are also provided.
Claims13
A method of preventing renal disease in a subject at risk of developing renal disease comprising administering a therapeutically effective amount of 2-methylene-19-nor-20(S)-1,25-dihydroxyvitamin D3 or pharmaceutically acceptable salts thereof to the subject without inducing hypercalcemia in the subject, wherein renal disease is prevented.
A method of preventing symptoms of renal disease in a subject at risk of developing symptoms of renal disease comprising administering a therapeutically effective amount of 2-methylene-19-nor-20(S)-1,25-dihydroxyvitamin D3 or pharmaceutically acceptable salts thereof to the subject without inducing hypercalcemia in the subject, wherein the symptoms of the renal disease are prevented.
A method for treating symptoms of renal disease in a subject having symptoms of renal disease comprising administering a therapeutically effective amount of 2-methylene-19-nor-(20s)-1α25 dihydroxy-vitamin D3 (2MD) or pharmaceutically acceptable salts thereof to the subject without inducing hypercalcemia in the subject, wherein the symptoms of renal disease are treated.
Dependencies are inferred from the claim text.