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US 2011/0034395 A1Published application
Compositions and methods of inhibiting apoptosis
AssigneeCase Western Reserve University
InventorSHIGEMI MATSUYAMA
Life of this patent
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Abstract
A method of inhibiting apoptosis in a cell includes administering to a cell an effective amount of a cell penetrating peptide (CPP), wherein the CPP consists of about 5 to about 41 amino acids and is substantially homologous to a portion of the C-terminal region of IFNγR2.
Claims26
A method of inhibiting apoptosis in a cell comprising:
- administering to the cell a therapeutically effective amount of cell penetrating peptide (CPP), the CPP consisting of about 5 to about 41 amino acids and being substantially homologous to a portion of the C-terminal region of IFNγR2.
A cell penetrating peptide (CPP) for inhibiting apoptosis in a cell consisting of about 5 to about 10 amino acids and including the amino acids of SEQ ID NO:2.
A pharmaceutical composition comprising:
- a cell penetrating peptide (CPP), the CPP consisting of about 5 to about 41 amino acids and being substantially homologous to a portion of the C-terminal region of IFNγR2;
- a Ku70-derived Bax-inhibiting peptide having the formula X6PX7LX8X9 (SEQ ID NO:4), wherein X6 is selected for amino acids with non-polar side chain, X7 is selected for amino acids with non-polar side chain, X8 is selected for amino acids with charged polar side chain, X9 is selected for amino acids with charged polar side chain, and either X6 or X9 may be absent;
- and
- a pharmaceutical carrier.
1 more element
A method of treating an apoptotic disease in a subject, comprising:
- administering to the subject a therapeutically effective amount of a cell penetrating peptide (CPP), the CPP consisting of about 5 to about 41 amino acids and being substantially homologous to a portion of the C-terminal region of IFNγR2.
Dependencies are inferred from the claim text.