Collagen and fibrin microthreads in a discrete thread model of in vitro acl scaffold regeneration
AssigneeWorcester Polytechnic Institute
InventorsKevin G. Cornwell, George D. Pins, Kristen Billiar
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Abstract
Compositions that include fibrin microthreads are provided. The compositions can include one or more therapeutic agents including cytokines and interleukins, extracellular matrix proteins and/or biologically active fragments thereof (e.g., RGD-containing peptides), hormones, vitamins, nucleic acids, chemotherapeutics, antibiotics, and cells. Also provided are methods of making compositions that include fibrin microthreads. Also provided are methods for using the compositions to repair or ameliorate damaged or defective organs or tissues.
Claims50
A method of making a fibrin microthread composition, the method comprising:
- (a) providing fibrinogen and a sufficient amount of a molecule capable of forming fibrin from the fibrinogen;
- and
- (b) extruding a mixture of the fibrinogen and the molecule through an orifice into a medium thereby producing a fibrin microthread.
The method of claim 56, wherein the subject is human.
An article of manufacture comprising a measured amount of fibrin microthreads and one or more items selected from the group consisting of packaging material, a package insert comprising instructions for use, and a sterile container.
Dependencies are inferred from the claim text.