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US 2011/0034387 A1Published application
Polypeptide inhibiting angiogenesis and application thereof
AssigneeShanghai First People's Hospital
InventorsHui Zhao, Xun Xu
Life of this patent
Estimating the term…
Abstract
Provided is a low molecular polypeptide that can inhibit angiogenesis consisting of amino acid sequence YRGKKA, which is same to one portion sequence in apolipoprotein (a) Kringle V. Also provided are pharmaceutical composition and the uses for preventing or treating diseases relating to angiogenesis.
Claims10
A polypeptide represented by the following formula I, or a pharmaceutically acceptable salt thereof,
- [Xaa0]-[Xaa1]-[Xaa2]-[Xaa3]-[Xaa4]-[Xaa5]-[Xaa6]-[Xaa7] (I)
- wherein,
- Xaa0 is not present, or a peptide segment consisting of 1-3 amino acids;
- Xaa1 is selected from the group consisting of Tyr or Phe;
- Xaa2 is selected from the group consisting of Arg or Lys;
- Xaa3 is selected from the group consisting of Gly or Ala;
- Xaa4 is selected from the group consisting of Lys or Arg;
- Xaa5 is selected from the group consisting of Lys or Arg;
- Xaa6 is selected from the group consisting of Ala, Val, Leu or Ile;
- Xaa7 is not present, or a peptide segment consisting of 1-3 amino acids;
- and said polypeptide exhibits an activity of inhibiting angiogenesis.
8 more elements
A method for inhibiting angiogenesis in a mammal, comprising the step of administering a subject in need thereof with the polypeptide or a pharmaceutically acceptable salt thereof of the present invention.
Dependencies are inferred from the claim text.