Cxcl12 gamma a chemokine and uses thereof
AssigneeInstitut Pasteur
InventorsFernando Arenzana, Hugues Lortat-Jacob, Francoise Baleux
Life of this patent
Estimating the term…
Abstract
Fragments of CXCL12 Gamma A chemokine having improved chemotaxis activity in vivo defined by an unprecedented capacity to associate and immobilise on extracellular glycans.
Claims22
A composition comprising at least
- a polypeptide sequence binding Glycosaminoglycans and/or fragments thereof;
- and
- a molecule of interest.
A composition comprising a homing molecule and a molecule of interest, wherein the homing molecule comprises a polypeptide of formula [BBXB]n;
- wherein B is a basic amino acid selected from the group consisting of arginine, lysine, and histidine, X is any other amino acid;
- and
- n is an integer comprised between 2 and 5.
A purified or chemically synthesized polypeptide of formula [BBXB]n wherein B is a basic amino acid selected from the group consisting of arginine, lysine, and histidine, X is any other amino acid and n is an integer from 2 to 5.
A purified polypeptide having the C-terminal fragment of the CXCL2gamma or a fragment containing at least 15 amino acids comprising at least two BBXB motifs.
15-20. (canceled)
A method of testing comprising:
- using a composition as a research tool, wherein the composition is selected from the group consisting of:
- a composition comprising at least a polypeptide sequence binding Glycosaminoglycans and/or fragments thereof, and a molecule of interest;
- a composition comprising a homing molecule and a molecule of interest, wherein the homing molecule comprises a polypeptide of formula [BBXB]n, B is a basic amino acid selected from the group consisting of arginine, lysine, and histidine, X is any other amino acid, and n is an integer comprised between 2 and 5;
- a purified or chemically synthesized polypeptide of formula [BBXB]n, wherein B is a basic amino acid selected from the group consisting of arginine, lysine, and histidine, X is any other amino acid. and n is an integer from 2 to 5;
- and
- a composition comprising a homing molecule and a molecule of interest, wherein the homing molecule comprises a polypeptide of formula [BBXB]n, B is a basic amino acid selected from the group consisting of arginine, lysine, and histidine, X is any other amino acid, and the homing molecule comprises the amino sequence GRREEKVGKKEKIGKKKRQKKRKAAQKRKN (SEQ ID NO:
- 1) and/or a variant thereof comprising the core sequence that enables the haptotactic homing activity and having at least the amino acid sequence of at least two BBXB motifs and wherein the variant has a basic charge for the whole molecule.
Dependencies are inferred from the claim text.