Signatures Associated with Rejection or Recurrence of Cancer
OwnerMasoud Manjili, Maciej Kmieciak +3inventors
InventorsMasoud Manjili, Maciej Kmieciak, Harry D. Bear, Catherine I. Dumur, Michael O. Idowu
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Abstract
Methods and tools for assessing the prognosis for patients following treatment of primary tumors are provided. The methods involve identifying immune-related genetic markers whose differential expression patterns at tumor lesions are indicative of either tumor recurrence or recurrence-free survival. The methods and tools of the invention assist physicians by providing objective decision-making tools for planning patient treatment protocols.
Claims15
A method for determining a probability of relapse of a patient with a tumor, comprising the steps of
- obtaining a sample of said tumor;
- measuring expression levels of immune system genes associated with said tumor;
- determining, using said expression levels of said immune system genes, a pattern of expression of immune system genes associated with said tumor;
- and,
- based on said pattern of expression, assigning said patient to a group selected from the group consisting of:
- i) patients who are likely to experience a relapse;
- and
- ii) patients who are unlikely to experience a relapse.
A method for developing a treatment protocol for a patient with a tumor, comprising the steps of
- obtaining a sample of said tumor;
- determining a pattern of expression of immune system genes in said tumor;
- based on said pattern of expression of immune system genes, categorizing said patient as a patient that is likely to undergo a relapse or as a patient that is unlikely to undergo a relapse;
- and
- developing a treatment protocol for said patient based on results obtained in said categorizing step.
A system for determining a probability of relapse of a patient with a tumor, said system comprising
- means for obtaining measurements of expression of immune system genes in tumors;
- means for recognizing, using said measurements, patterns of gene expression, wherein said patterns of gene expression are correlated with said probability of relapse;
- and
- means for assigning a probability of relapse to said patient with said tumor.
A microarray chip for analyzing the likelihood of relapse of a patient with a tumor, comprising
- primers specific for amplifying RNA corresponding to genes listed in-Table 4 and Table 5.
Dependencies are inferred from the claim text.