Method for obtaining ngn3-expressing cells and insulin producing-beta cells
OwnerRaphael Scharfmann, Cecile Haumaitre-Sarron +1inventors
InventorsRaphael Scharfmann, Cecile Haumaitre-Sarron, Olivia Lenoir
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Abstract
The present invention relates to a method for obtaining Ngn3-expressing cells and insulin producing-beta cells by contacting a Pdx1-expressing pancreas explant with an amount of at least one histone deacetylase inhibitor (HDACi). The inventive methods have the advantage of being simple and quick, and of providing large amounts of Ngn3-expressing cells and insulin producing-beta cells, that are useful therapeutic tools. The invention also relates to a pharmaceutical composition for the treatment of diabetes which comprises an amount of at least one HDACi.
Claims11
A method for obtaining a population of insulin producing-beta cells which comprises a step of contacting a Pdx1-expressing pancreatic explant with an amount at least one histone deacetylase inhibitor (HDACi).
A method for obtaining a population of insulin producing-beta cells which comprises a step of contacting Ngn3-expressing cells with an amount at least one HDACi.
A method for obtaining a population of Ngn3-expressing cells which comprises a step of contacting a Pdx1-expressing pancreatic explant with an amount at least one HDACi.
A pharmaceutical composition for the treatment of diabetes which comprises an amount of at least one HDACi.
Dependencies are inferred from the claim text.