Marker for stem cells and its use
AssigneeXintela AB
InventorEvy Lundgren-Akerlund
Life of this patent
Estimating the term…
Abstract
A marker for mesenchymal stem cells (MSC) is provided, comprising an integrin alpha10 chain and/or an integrin alpha11 chain expressed on the cell surface of or intracellular in a MSC. The marker is used in methods for identification of mammalian MSC and in methods for isolation of MSC. Also included are isolated cellular populations of mammalian MSC and a cellular composition comprising the latter. Moreover, uses of said marker for isolation, modulation and identification of mammalian MSC are provided.
Claims7
-8. (canceled)
A method for producing an isolated population of mammalian cells enriched for mesenchymal stem cells relative to a reference population, the method comprising the steps of
- a) providing at least a portion of a population of cells, or a portion of a reference population, comprising at least one mesenchymal stem cell and at least one cell other than a mesenchymal stem cell,
- b) introducing into the population of cells in a) above a compound identifying an integrin alpha 10 chain or integrin alpha 10 and integrin alpha 11 chain expressed on the cell surface of mesenchymal stem cells or intracellular in mesenchymal stem cells,
- c) selecting and isolating from the population of cells in b) above the mesenchymal stem cell(s), thereby producing a population of cells enriched for mesenchymal stem cells.
12-16. (canceled)
A method for isolating a mammalian mesenchymal stem cell comprising utilizing a marker comprising an integrin alpha 10 chain or an integrin alpha 10 chain and an integrin alpha 11 chain expressed on the cell surface of a mesenchymal stem cell or intracellular in a mesenchymal stem cell.
Dependencies are inferred from the claim text.