Rotating bioreactor
AssigneeHarvard Bioscience, Inc.
InventorsMaria Adelaide Asnaghi, Sara Mantero
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Abstract
Articles and methods for growing tissues and organs using bioreactors, including rotating bioreactors, are provided. In some embodiments, a bioreactor is configured to provide a first and second chamber, such as an inner and an outer chamber, respectively. The chambers may be co-axially arranged with respect to each other. A wall of the bioreactor defining the two chambers may be formed at least in part from a scaffold derived from a length of a hollow or tubular tissue or organ. Such a bioreactor can be used to form biocompatible structures for tissue engineering and organ replacement, such as cellular tissues, organ-like structures, and/or complete organs, within the bioreactor.
Claims18
A bioreactor, comprising:
- a vessel;
- a scaffold defining an outer wall of an inner chamber and an inner wall of an outer chamber, wherein the scaffold is configured to rotate about a central axis;
- a shaft positioned within the inner chamber, the shaft comprising an opening defining a first inlet for introducing a liquid into the inner chamber;
- a first outlet in fluid communication with the inner chamber;
- and
- an opening in fluid communication with the outer chamber for introducing and/or removing a liquid from the outer chamber.
Dependencies are inferred from the claim text.