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US 2011/0033898 A1Published application
Method for producing 5'-guanylic acid
AssigneeAjinomoto Co., Inc.
InventorsHiroaki Fukada, Takayuki Asahara, Kenichi Hashiguchi
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Abstract
5′-guanylic acid (GMP) is produced efficiently by allowing a microorganism to react with xanthylic acid (XMP), wherein said microorganism is able to convert xanthylic acid into 5′-guanylic acid and has been modified so that the nagD gene does not function normally and 5′-guanylic acid synthetase activity is enhanced.
Claims12
A method for producing 5′-guanylic acid comprising:
- A) reacting a microorganism with xanthylic acid to produce 5′-guanylic acid, and
- B) collecting 5′-guanylic acid;
- wherein said microorganism is able to convert xanthylic acid into 5′-guanylic acid, and has been modified so that:
- a) a nagD gene does not function normally, and
- b) 5′-guanylic acid synthetase activity is enhanced.
2 more elements
A microorganism which is able to convert xanthylic acid into 5′-guanylic acid, wherein said microorganism has been modified so that:
- a) 5′-guanylic acid synthetase activity is enhanced by increasing expression of a guaA gene, and
- b) a nagD gene does not function normally,
- wherein said microorganism does not have increased expression of a guaB gene.
Dependencies are inferred from the claim text.