Gdf-15 as biomarker in type 1 diabetes
OwnerGeorg Hess, Andrea Horsch +1inventors
InventorsGeorg Hess, Andrea Horsch, Dietmar Zdunek
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Abstract
The present invention relates to a method of predicting if a diabetes type 1 patient will suffer from one or more complications selected from cardiovascular complications, terminal renal failure, and death, the method including (a) determining the amount of GDF-15 in a sample of a diabetes type 1 patient; and (b) comparing the amount of GDF-15 determined in step (a) to a reference amount and establishing a prediction. Also encompassed by the present invention are devices and kits for carrying out the aforementioned methods.
Claims8
A method for predicting susceptibility of terminal renal failure in a type 1 diabetes patient, the method comprising:
- determining an amount of growth-differentiation factor 15 (GDF-15) in a sample from the patient, and
- comparing the amount of GDF-15 determined to a reference amount of GDF-15 wherein a prediction of susceptibility of terminal renal failure in the subject is indicated when the determined amount of GDF-15 is greater than the reference amount.
A method for assessing a risk of a diabetes type 1 patient suffering from terminal renal failure, the method comprising:
- determining the amount of GDF-15 in a sample from a diabetes type 1 patient and
- comparing the amount of GDF-1.5 determined to a reference amount of GDF-15 wherein a risk of terminal renal failure in the patient is indicated when the determined amount of GDF-15 is greater than the reference amount.
A method for deciding on administration of medicament in a diabetes type 1 patient who has a susceptibility of terminal renal failure, the method comprising
- determining an amount of growth-differentiation factor 15 (GDF-15) in a sample from the patient, and
- comparing the amount of GDF-15 determined to a reference amount of GDF-15 wherein a decision for administration of medicament is indicated when the determined amount of GDF-15 is greater than the reference amount.
Dependencies are inferred from the claim text.