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AssigneeGene Security Network, Inc.
InventorsMatthew Rabinowitz, David S. Johnson, Johan Baner, Zachary Demko, Cengiz Cinnioglu
Estimating the term…
Methods for cell genotyping are disclosed herein. A method for determining the genomic data of one or a small number of cells, or from fragmentary DNA, where a limited quantity of genetic data is available may include adding one or more targeted primers to a whole genome amplification of a cell, increasing the accuracy with which key alleles are measured in the context of a whole genome amplification. The genetic material from a single cell may be divided into fractions, each of which may be separately genotyped, allowing the reconstruction of the cells haplotype. The genetic material from a single cell may be divided into fractions, each of which may be separately genotyped, and the distribution of the various alleles in the different fractions may be used to determine the ploidy state of one or a plurality of chromosomes in the cell.
A method of performing genome amplification on a nucleic acid sample from a subject, the method comprising:
A method for determining the haplotype of a DNA sample, the method comprising:
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A method for determining the ploidy state of one or more chromosomes of a single cell containing nuclear DNA, wherein a given chromosome is associated with a known set of alleles, the method comprising:
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Dependencies are inferred from the claim text.