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US 2011/0033859 A1Published application
RNAi INHIBITION OF INFLUENZA VIRUS REPLICATION
AssigneeAlnylam Pharmaceuticals, Inc.
InventorsAntonin de Fougerolles, Tatiana Novobrantseva, Pamela Tan, Anke Geick, Rachel Meyers
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Abstract
The invention relates to compositions and methods for modulating the expression of influenza viral genes, and more particularly to the downregulation of influenza viral genes by chemically modified oligonucleotides.
Claims20
A method of enhancing gene expression of an influenza gene in cell culture comprising,
- (a) contacting a cell culture with an RNA agent, wherein the cells of said cell culture have been engineered to express a recombinant influenza target gene;
- (b) measuring the level of gene expression of said recombinant influenza target gene;
- and
- (c) comparing the level of expression determined in step (c) to the level of expression in mock-treated cells, wherein an increased level of expression over mock-treated cells is evidence that enhanced gene expression of an influenza gene has occurred.
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Dependencies are inferred from the claim text.