Methods relating to aromatase inhibitor pharmacogenetics
AssigneeThe Penn State Research Foundation
InventorsPHILIP LAZARUS, DONGXIAO SUN
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Abstract
Methods for aiding in determining therapeutic efficacy of an aromatase inhibitor in a subject are provided according to embodiments of the present invention which include detecting expression and/or function of at least one UDP-glucuronosyltransferase having activity to modify at least one aromatase inhibitor and/or metabolite of the aromatase inhibitor by glucuronidation, wherein detection of expression and/or function of the UDP-glucuronosyltransferase is correlated with therapeutic efficacy of the aromatase inhibitor in the subject. Detection of UDP-glucuronosyltransferase expression and/or function includes detection of a UDP-glucuronosyltransferase gene deletion polymorphism in the subject
Claims20
A method for aiding in determining therapeutic efficacy of exesmestane in a subject, comprising:
- assaying a biological sample obtained from the subject for a UDP glucuronosyltransferase 2 family, polypeptide B17 gene deletion polymorphism, wherein detection of the UDP glucuronosyltransferase 2 family, polypeptide B17 gene deletion polymorphism is correlated with altered therapeutic efficacy of the exesmestane in the subject.
A method of detecting exesmestane use in a subject, comprising:
- assaying a biological sample obtained from the subject for a UDP glucuronosyltransferase 2 family, polypeptide B17 gene deletion polymorphism, wherein detection of the UDP glucuronosyltransferase 2 family, polypeptide B17 gene deletion polymorphism is correlated with decreased production of glucuronidated 17-dihydroexemestane in the urine of the subject, wherein detecting no UDP glucuronosyltransferase 2 family, polypeptide B17 gene deletion polymorphism supports a finding of no exemestane use in the subject when glucuronidated 17-dihydroexemestane is not detected in urine.
A method for aiding in determining therapeutic efficacy of an aromatase inhibitor in a subject, comprising:
- detecting expression and/or function of at least one UDP-glucuronosyltransferase having activity to modify at least one aromatase inhibitor and/or metabolite of the aromatase inhibitor by glucuronidation, wherein detection of expression and/or function of the UDP-glucuronosyltransferase is correlated with therapeutic efficacy of the aromatase inhibitor in the subject.
Dependencies are inferred from the claim text.