Use of lysosomal carboxypeptidase c (prcp) as a therapeutic or diagnostic target
AssigneeBayer HealthCare LLC
InventorsStefan Golz, Ulf Brüggemeier, Adreas Geerts
Life of this patent
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Abstract
The invention provides a human PRCP which is associated with the cardiovascular diseases, hematological diseases, neurological diseases and cancer. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, hematological diseases, neurological diseases and cancer. The invention also features compounds which bind to and/or activate or inhibit the activity of PRCP as well as pharmaceutical compositions comprising such compounds.
Claims17
A method of screening for therapeutic agents useful in the treatment of cardiovascular diseases, hematological diseases, neurological diseases or cancer in a mammal comprising the steps of:
- contacting a test compound with a PRCP polypeptide, and
- detect binding of said test compound to said PRCP polypeptide;
- or
- determining the activity of a PRCP polypeptide at a certain concentration of a test compound or in the absence of said test compound, and
- determining the activity of said polypeptide at a different concentration of said test compound;
- or
- determining the activity of a PRCP polypeptide at a certain concentration of a test compound, and
- determining the activity of a PRCP polypeptide at the presence of a compound known to be a regulator of a PRCP polypeptide.
2-3. (canceled)
A method of screening for therapeutic agents useful in the treatment of cardiovascular diseases, hematological diseases, neurological diseases or cancer in a mammal comprising the steps of:
- contacting a test compound with a PRCP polynucleotide,
- detect binding of said test compound to said PRCP polynucleotide;
- or
- determining the amount of a PRCP polynucleotide in a sample taken from said mammal,
- determining the amount of PRCP polynucleotide in healthy and/or diseased mammals.
18-26. (canceled)
Dependencies are inferred from the claim text.