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US 2011/0033706 A1Published application
Nanocapsules and methods for modular assembly
OwnerYamuna Krishnaninventor
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Abstract
Disclosed are nanocapsules and methods of preparing these nanocapsules. The disclosure includes a modular assembly method of forming DNA nanocapsules. Discrete polyhedra are combined in a stepwise amalgamation to form icosahedra. The DNA nanocapsules may be used to encapsulate agents for drug delivery and other applications.
Claims20
An iscosahedral nanocapsule comprising:
- (a) one or more first five-way-junction (5WJ) modules each having a star-like configuration, wherein each first 5WJ module comprises five single-stranded oligonucleotides;
- (b) one or more second 5WJ modules each having a star-like configuration, wherein each second 5WJ module comprises five single-stranded oligonucleotides;
- and
- (c) one or more third 5WJ modules each having a star-like configuration, wherein each third 5WJ module comprises five single-stranded oligonucleotides;
- wherein the first 5WJ modules, the second 5WJ modules, and the third 5WJ modules are configured to interact to form an icosahedral nanocapsule.
2 more elements
A half-icosahedral structure for the modular assembly of icosahedral nanocapsules, the structure comprising:
- (a) one first 5WJ module having a star-like configuration, wherein each first 5WJ module comprises five single-stranded oligonucleotides;
- (b) five second 5WJ modules each having a star-like configuration, wherein each second 5WJ module comprises five single-stranded oligonucleotides;
- wherein the first 5WJ module and the second 5WJ modules are configured to interact to form a half-icosahedral structure.
A method for assembling an icosahedral nanocapsule, the method comprising:
- (a) combining one or more first 5WJ modules with one or more second 5WJ modules to form a first six vertex structure, wherein each 5WJ module has a star-like configuration and comprises five single-stranded oligonucleotides;
- (b) combining one or more third 5WJ modules with one or more fourth 5WJ modules to form a second six vertex structure, wherein each 5WJ module has a star-like configuration and comprises five single-stranded oligonucleotides, and wherein the first 5WJ module and the third 5WJ module may be the same or different;
- and
- (c) combining the first and second six vertex structures to form an icosahedral nanocapsule.
1 more element
Dependencies are inferred from the claim text.