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US 2011/0033554 A1Published application
Method of Viral Inactivation of Biological Fluids
AssigneeResearch Foundation for Medical Devices
InventorsThierry Burnouf, Magdy El-Ekiaby, Hadi Alphonse Goubran, Miryana Radosevich
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Abstract
The invention relates to a novel method of virally inactivating biological fluids by solvent/detergent treatment of the fluid, followed by oil extraction and filtration.
Claims12
A method of virally inactivating a biological fluid comprising:
- (a) a step of treating the biological fluid with a mixture of tri(n-butyl)phosphate and polyoxyethylene (4-5) p-t-octyl-phenol (t-Oct-C6H4—(OCH2CH2)xOH, x≈5);
- (b) an oil extraction step, wherein the tri(n-butyl)phosphate and polyoxyethylene (4-5) p-t-octyl-phenol (t-Oct-C6H4—(OCH2CH2)xOH, x≈5) containing biological fluid is treated with 5 to 15 volume % of soybean oil with respect to the volume of the biological fluid so as to transfer tri(n-butyl)phosphate and polyoxyethylene (4-5) p-t-octyl-phenol (t-Oct-C6H4-(OCH2CH2)xOH, x≈5) from the biological fluid to the soybean oil;
- (c) passing the biological fluid recovered after step (b) through an activated charcoal filter;
- and
- (d) passing the biological fluid recovered after step (c) through a bacterial filter;
- provided that the soybean oil extraction step is the sole oil extraction step of the method.
3 more elements
A virally-inactivated biological fluid selected from the group consisting of plasma, cryo-poor plasma, and cryoprecipitate, wherein the biological fluid is essentially free of lipids and free of blood cells and cell debris.
Dependencies are inferred from the claim text.