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US 2011/0033543 A1Published application
Hydrogels with covalent and noncovalent crosslinks
AssigneeUniversity of Delaware
InventorsKristi L. Kiick, Nori Yamaguchi
Life of this patent
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Abstract
A method for targeted delivery of therapeutic compounds from hydrogels is presented. The method involves administering to a cell a hydrogel in which a therapeutic compound is noncovalently bound to heparin. The hydrogel may contain covalent and non-covalent crosslinks.
Claims20
A hydrogel comprising:
- a polymer matrix comprising a noncovalent crosslink and a covalent crosslink,
- wherein the noncovalent crosslink comprises a first and a second PEG-LMWH conjugate and a heparin-binding compound, wherein the PEG molecule of each conjugate is covalently attached to the polymer matrix, and wherein the LMWH molecule of each conjugate is covalently attached to the PEG molecule of the same conjugate and noncovalently attached to the heparin-binding compound, and
- wherein the covalent crosslink comprises a first and a second PEG molecule and a LMWH molecule, wherein each PEG molecule is covalently attached to the polymer matrix and covalently attached to the LMWH molecule.
A hydrogel comprising:
- a polymer matrix comprising a noncovalent crosslink and a covalent crosslink,
- wherein the noncovalent crosslink comprises a first and a second PEG-LMWH conjugate and a first heparin-binding compound, wherein the PEG molecule of each conjugate is covalently attached to the polymer matrix, and wherein the LMWH molecule of each conjugate is covalently attached to the PEG molecule of the same conjugate and noncovalently attached to the first heparin-binding compound, and
- wherein the covalent crosslink comprises either
- (i) a third and a fourth PEG-LMWH conjugate and a second heparin-binding compound, wherein the PEG molecule of each conjugate is covalently attached to the polymer matrix, wherein the LMWH molecule of each conjugate is covalently attached to the PEG molecule of the same conjugate, and wherein the LMWH molecule of each conjugate is either covalently attached to the second heparin-binding compound or wherein the LMWH molecule of the third conjugate is covalently attached and the LMWH molecule of the fourth conjugate is noncovalently attached to the second heparin-binding compound, or
- (ii) a first and a second PEG molecule and a third heparin-binding compound, wherein each PEG molecule is covalently attached to the polymer matrix and covalently attached to the third heparin-binding compound.
2 more elements
Dependencies are inferred from the claim text.