Polymer formulations for delivery of bioactive agents
AssigneeCarbylan Therapeutics, Inc.
InventorsGeorge Daniloff, David Gravett, Robert C. Spiro
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Abstract
Disclosed in the present application are compositions comprising a bioresorbable polymer matrix and a bio active agent, wherein the bioactive agent is dispersed within polymer matrix as a solid. Also provided herein are methods for preparing a bioactive agent formulation, wherein the agent is present in a solid form and, wherein the agent is occluded into a polymeric matrix by polymerization of polymer matrix precursors or by self assembly of the polymer.
Claims33
A composition comprising an in situ crosslinkable modified hyaluronic acid, wherein the modified hyaluronic acid is a flowable liquid with an initial viscosity of between 2 and 150,000 mPa·s, wherein the hyaluronic acid polymerizes in situ and forms a hydrogel with an elastic modulus of less than 0.1 GPa when the composition comprising the modified hyaluronic acid and initiator is applied on a tissue of a mammal.
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A composition comprising a thiol functionalized hyaluronic acid comprising a bioactive agent, wherein the hyaluronic acid is in a form of a bioresorbable polymer matrix and the bioactive agent is dispersed within the polymer matrix as a solid.
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Dependencies are inferred from the claim text.