Pharmaceutical composition as solid dosage form and method for manufacturing thereof

A method for the manufacturing of a pharmaceutical composition as a solid dosage form comprising desmopressin, or a pharmaceutically acceptable salt thereof, as a therapeutically active ingredient, wherein said method comprises the steps of:

• (i) mixing desmopressin and an excipient, diluent or carrier, or mixture thereof, optionally in the presence of a wetting agent;
• (ii) subjecting the resulting mixture to formation of a granulate, optionally in the presence of a wetting agent, suitable for compression into said solid dosage form;
• (iii) optionally performing said mixing and/or formation of a granulate in the presence of at least one additive selected from a disintegrating agent, binder, flavoring agent, preservative, colorant and a mixture thereof;
• (iv) optionally drying said granulate;
• (v) compressing said granulate into said solid dosage form;
• wherein lubricant is introduced so that the resulting pharmaceutical composition contains lubricant in an amount of from 0.05 to less than 0.50 percent by weight of said pharmaceutical composition.