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US 2011/0033527 A1Published application
Opthalmic compositions of cyclosporin
OwnerNian Wu, Brian Charles Kellerinventors
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Abstract
Lipid-polymer compounds are used to solubilize cyclosporin. Diacylglycerol-polyethyleneglycols (DAG-PEGs) are especially useful in this regard. A preferred embodiment of the invention is an aqueous solution of cyclosporin suitable for opthalmic use.
Claims13
A method of solubilizing cyclosporin, the method comprising:
- selecting an amphipathic PEG-lipid conjugate having a melting temperature below about 25 degrees Centigrade;
- and
- adding the cyclosporin to the conjugate with mixing.
An aqueous solution of solubilized cyclosporine comprising
- an amphipathic PEG-lipid conjugate having a melting temperature below about 25 degrees Centigrade;
- and
- cyclosporine at a concentration between about 0.1 and 1.0 percent by weight.
A pharmaceutical composition comprising:
- a first amphipathic PEG conjugate, said first conjugate having a melting temperature below about 25 degrees Centigrade;
- a second amphipathic PEG conjugate having a melting temperature above about 25 degrees Centigrade;
- cyclosporine at a weight to weight ration of between about 1 and 10 of the total amount of conjugates to cyclosporin;
- and
- a capsule coating suitable for oral ingestion.
2 more elements
Dependencies are inferred from the claim text.