Combination dosage form of low-dose modafinil and low-dose sildenafil
OwnerAdel Penhasi, Janina Gauchman +3inventors
InventorsAdel Penhasi, Janina Gauchman, Amanda Shauli, Marina Ruderman, Avi Avramoff
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Abstract
Modified release formulations comprising at least one of modafinil and sildenafil, and combinations thereof, and a time-controlled delivery system coating.
Claims36
A composition comprising:
- a core comprising at least one of a wakefulness-inducing agent and a phosphodiesterase type 5 inhibitor as active ingredient and;
- a time-controlled delivery system (TCDS) coating, wherein said TCDS coating controls release of said active ingredient in said core as a delayed onset, slow release formulation.
A method of achieving one or more of increasing wakefulness, treatment or prevention of sleepiness, treatment or prevention of jetlag, treatment or prevention of sleep disorders associated with excessive sleepiness, and reduction or prevention of sleepiness throughout a desired period, comprising administering a composition comprising a core comprising at least one of a wakefulness-inducing agent and a phosphodiesterase type 5 inhibitor as active ingredient and a time-controlled delivery system (TCDS) coating.
A synergistic dosage form for treating sleep related disorders, comprising a synergistic combination of a PDE5 inhibitor and a wakefulness inducing agent.
Dependencies are inferred from the claim text.