Recombinant bacterium capable of eliciting an immune response against enteric pathogens
AssigneeArizona Board of Regents for and on behalf of Arizona State University
InventorsRoy Curtiss iii, Melha Mellata, Bereket Zekarias, Zhaoxing Shi, Christine Branger, Kenneth Roland
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Abstract
The present invention relates to a recombinant bacterium that is capable of eliciting an immune response against at least two enteric pathogens, without substantially inducing an immune response specific to the serotype of the bacterium. The invention also relates to methods of making such a bacterium and vaccines and methods of using such a bacterium.
Claims35
A recombinant Salmonella bacterium, wherein the bacterium is capable of the expression of at least one nucleic acid encoding at least two enteric antigens, such that the bacterium, when administered to a host, is capable of eliciting an immune response against at least two enteric pathogens in addition to at least one Salmonella serotype.
Dependencies are inferred from the claim text.