Vaccine
AssigneesJohn Stambas, Christina Cheers, The Austin Research Institute, Melbourne, University of, the
InventorsIan Farquhar Campbell McKenzie, Geoffrey Allan Pietersz, Christina Cheers, John Stambas
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Abstract
The present invention provides a method of immunising a subject comprising the step of administering a composition comprising an antigen and a carbohydrate polymer comprising mannose to a mucosal site of the subject, methods of use of the composition for vaccination and sterilization and use of the composition in manufacturing a medicament.
Claims14
1-16. (canceled)
A method of immunising a subject in need thereof, comprising the step of intranasally administering a composition comprising:
- a conjugate consisting of antigen, aldehyde groups and a carbohydrate polymer, wherein the polymer:
- a) comprises mannose monomers oxidized to produce aldehyde groups, and
- b) is covalently bonded to the antigen,
- thereby stimulating an immune response comprising a secretory immune response.
A method of modulating an immune response comprising a secretory immune response at a mucosal site in a subject in need thereof comprising the step of intranasally administering a composition comprising a conjugate consisting of antigen, aldehyde groups and a carbohydrate polymer, wherein the polymer:
- a) comprises mannose monomers oxidized to produce aldehyde groups, and
- b) is covalently bonded to the antigen.
A method of vaccinating a subject in need thereof against a disease comprising the step of intranasally administering to the subject a composition comprising a conjugate consisting of antigen, aldehyde groups and a carbohydrate polymer, wherein the polymer:
- a) comprises mannose monomers oxidized to produce aldehyde groups;
- and
- b) is covalently bonded to the antigen;
- thereby generating an immune response comprising a secretory immune response.
Dependencies are inferred from the claim text.