Vaccines and diagnostics for the ehrlichioses
AssigneeResearch Development Foundation
InventorsJere W. McBride, Tian Luo
Life of this patent
Estimating the term…
Abstract
The present invention concerns VLPT immunoreactive compositions for E. chaffeensis and compositions related thereto, including vaccines, antibodies, polypeptides, peptides, and polynucleotides. In particular, epitopes for E. chaffeensis VLPT are disclosed.
Claims28
A polypeptide composition, comprising one or more of the following:
- (a) an isolated polypeptide comprising one or more amino acid sequences selected from the group consisting of:
- SEQ ID NO:3;
- SEQ ID NO:4;
- SEQ ID NO:5;
- SEQ ID NO:8;
- SEQ ID NO:9;
- SEQ ID NO:10;
- and SEQ ID NO:11;
- or
- (b) an isolated polypeptide that is at least 95% identical to a polypeptide of (a).
An isolated antibody that immunologically reacts with one or more of the amino acid sequences selected from the group consisting of SEQ ID NO:3;
- SEQ ID NO:4;
- SEQ ID NO:5;
- SEQ ID NO:8;
- SEQ ID NO:9;
- SEQ ID NO:10;
- and SEQ ID NO:11.
An isolated antibody that immunologically reacts with the amino acid sequence SEQ ID NO:3.
An isolated antibody that immunologically reacts with the amino acid sequence SEQ ID NO:4.
An isolated antibody that immunologically reacts with the amino acid sequence SEQ ID NO:5.
An isolated antibody that immunologically reacts with the amino acid sequence SEQ ID NO:8.
An isolated antibody that immunologically reacts with the amino acid sequence SEQ ID NO:9.
An isolated antibody that immunologically reacts with the amino acid sequence SEQ ID NO:10.
An isolated antibody that immunologically reacts with the amino acid sequence SEQ ID NO:11.
A method of identifying an E. chaffeensis infection in an individual, comprising the step of assaying a sample from the individual for one of the following:
- (a) an isolated polypeptide comprising one or more amino acid sequences selected from the group consisting of:
- SEQ ID NO:3;
- SEQ ID NO:4;
- SEQ ID NO:5;
- SEQ ID NO:8;
- SEQ ID NO:9;
- SEQ ID NO:10;
- and SEQ ID NO:11;
- or
- (b) an antibody that immunologically reacts with an amino acid sequence selected from the group consisting of the polypeptides of (a).
25-34. (canceled)
37-44. (canceled)
Dependencies are inferred from the claim text.