Gene expression markers for crohn's disease
OwnerAlexander R. ABBAS, Hilary Clark +4inventors
InventorsAlexander R. ABBAS, Hilary Clark, Lauri Diehl, Charles Lees, Colin L. Noble, Jack Satsangi
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Abstract
The present invention relates to methods of gene expression profiling for inflammatory bowel disease pathogenesis, in which the differential expression in a test sample from a mammalian subject of one or more IBD markers relative to a control is determined, wherein the differential expression in the test sample is indicative of an IBD in the mammalian subject from which the test sample was obtained.
Claims43
A method of diagnosing the presence of an inflammatory bowel disease (IBD) in a mammalian subject, comprising determining a differential expression level of a nucleic acid encoding a polypeptide shown as any one of SEQ ID NOS:
- 5, 6, 8, 11, 12, 2, 14, 16, 18, 20, and 22 in a test sample obtained from the subject relative to the expression level of a control, wherein said differential level of expression is indicative of the presence of an IBD in the subject from which the test sample was obtained.
A method of treating an inflammatory bowel disorder (IBD) in a mammalian subject in need thereof, the method comprising the steps of
- (a) determining a differential expression level of a nucleic acid encoding a polypeptide shown as any one of SEQ ID NOS:
- 5, 6, 8, 11, 12, 2, 14, 16, and 18, in a test sample obtained from said subject relative to the expression level of a control, wherein said differential level of expression is indicative of the presence of an IBD in the subject from which the test sample was obtained;
- and
- (b) administering to said subject an effective amount of an IBD therapeutic agent.
Dependencies are inferred from the claim text.