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US 2011/0033485 A1Published application
Analogues of glycolipids useful as immunoadjuvants
AssigneeLuigi Panza
InventorLuigi Panza
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Abstract
The invention provides analogs of alpha-galactosyl ceramide that increase the immune response elicited by various antigens. It also provides methods of using such compounds to increase the effectiveness of vaccines.
Claims12
A compound of formula I:
- wherein R2, R3, R4, and R5 each independently represent H or a protecting group;
- X is a C4-C30 hydrocarbyl group that can be substituted;
- Y is a C1-C6 alkylene or C2-C6 alkenylene linker that can be substituted with up to two groups;
- and Z is —OR1, wherein R1 is a C4-C20 hydrocarbyl group that can contain a heteroatom within its backbone, and is optionally substituted;
- or a pharmaceutically acceptable salt thereof.
2 more elements
A method to increase the immune response elicited by an antigen, comprising administering to a subject receiving the antigen an effective amount of a compound of Formula I:
- wherein R2, R3, R4, and R5 each independently represent H or a protecting group;
- X is a C4-C30 hydrocarbyl group that can be substituted;
- Y is a C1-C6 alkylene or C2-C6 alkenylene linker that can be substituted with up to two groups;
- and Z is —OR1, wherein R1 is a C4-C20 hydrocarbyl group that can contain a heteroatom within its backbone, and is optionally substituted;
- or a pharmaceutically acceptable salt thereof.
2 more elements
Dependencies are inferred from the claim text.