LprG AS A CHAPERONE OF IMMUNE ADJUVANTS
AssigneeCase Western Reserve University
InventorsClifford V. Harding, W. Henry Boom, Michael G. Drage, Nicole D. Pecora
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Abstract
An adjuvant combination that stimulates immune activation or response includes a hydrophobic immune adjuvant and a pathogen derived lipoprotein that chaperones the hydrophobic immune adjuvant to an immune receptor.
Claims14
An adjuvant combination that stimulates an immune activation and/or response comprising:
- a hydrophobic immune adjuvant and a pathogen derived lipoprotein that chaperones the hydrophobic immune adjuvant to an immune receptor.
An immune stimulating complex comprising:
- a hydrophobic immune adjuvant and LprG, the LprG being present in an amount effective to chaperone the immune adjuvant to an immune receptor.
The immune stimulating complex, the hydrophobic immune adjuvant being a glycolipid immune adjuvant.
The immune stimulating complex, the hydrophobic immune adjuvant being at least one of a TLR2 agonist or TLR4 agonist.
A vaccine comprising:
- an antigen;
- a hydrophobic immune adjuvant;
- and
- LprG in an amount effective to chaperone the hydrophobic TLR agonist to a TLR.
Dependencies are inferred from the claim text.