Single-chain multivalent binding proteins with effector function
AssigneeTrubion Pharmaceuticals, Inc.
InventorsPeter Armstrong Thompson, Jeffrey A. Ledbetter, Martha Susan Hayden-Ledbetter, Laura Sue Grosmaire, Robert Bader, William Brady
Life of this patent
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Abstract
Multivalent binding peptides, including bi-specific binding peptides, having immunoglobulin effector function are provided, along with encoding nucleic acids, vectors and host cells as well as methods for making such peptides and methods for using such peptides to treat or prevent a variety of diseases, disorders or conditions, as well as to ameliorate at least one symptom associated with such a disease, disorder or condition.
Claims23
-98. (canceled)
A single-chain multispecific binding protein with effector function, comprising from amino-terminus to carboxy-terminus:
- (a) a first binding domain comprising variable regions from an immunoglobulin or immunoglobulin-like molecule;
- (b) a first linker peptide;
- (c) an immunoglobulin constant sub-region providing an effector function;
- (d) a second linker peptide;
- and
- (e) a second binding domain comprising variable regions from an immunoglobulin or immunoglobulin-like molecule;
- wherein the first and the second binding domains recognize different target molecules and have a binding affinity of at least 10−6 M.
Dependencies are inferred from the claim text.