Proteins ezrin, serpin b5, peroxiredoxin-2 and heat shock protein beta-1 as autoantigens for psoriasis vulgaris and poststreptococcal diseases
AssigneeLudwig-Maximilians-Universitat
InventorsJörg C. Prinz, Petra Besgen, Paul Trommler
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Abstract
The present invention relates to autoantigens selected from Ezrin, Serpin B5, Peroxiredoxin-2, heat shock protein β1, and/or peptides comprising at least 5 consecutive amino acid residues of one of these autoantigenic proteins having immunological activity, or fragments, variants, or epitopes thereof and/or mixtures of at least two of the proteins and/or peptides as diagnostic tool for the detection of streptococcal driven conditions or as therapeutical agent for the treatment of streptococcal driven conditions.
Claims25
1-40. (canceled)
A method for the detection of a streptococcal driven condition comprising detecting the presence of a humoral and/or a cellular immune response against at least one autoantigen selected from Ezrin, Serpin B5, Peroxiredoxin-2, heat shock protein β1, and/or peptides comprising at least 5 consecutive amino acid residues of one of these autoantigenic proteins having immunological activity, or fragments, variants, or epitopes thereof and/or mixtures of at least two of the proteins and/or peptides in a sample.
A method for treating streptococcal driven conditions wherein an autoantigen selected from Ezrin, Serpin B5, Peroxiredoxin-2, heat shock protein β1, and/or a peptide comprising at least 5 consecutive amino acid residues of one of these autoantigenic proteins having immunological activity, or fragments, variants, or epitopes thereof and/or mixtures of at least two of the proteins and/or peptides and/or an antibody or antibody fragment directed against at least one of the above autoantigens is administered to a patient in need thereof.
Dependencies are inferred from the claim text.