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US 2011/0033472 A1Published application
Tumor Endothelial Marker 5-alpha Molecules and Uses Thereof
AssigneeAmgen Inc.
InventorTodd Juan
Life of this patent
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Abstract
The present invention provides Tumor Endothelial Marker 5α (TEM5α) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing TEM5α polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, or prevention of diseases, disorders, and conditions associated with TEM5α polypeptides.
Claims14
An antibody or fragment thereof that specifically binds:
- (a) an isolated polypeptide comprising:
- (i) the amino acid sequence of SEQ ID NO:
- 2;
- (ii) the amino acid sequence of SEQ ID NO:
- 4;
- (iii) the amino acid sequence of SEQ ID NO:
- 2, further comprising an amino-terminal methionine;
- or
- (iv) the amino acid sequence of SEQ ID NO:
- 4, further comprising an amino-terminal methionine;
- or
- (b) an isolated polypeptide comprising an amino acid sequence that is encoded by:
- (i) the nucleotide sequence of SEQ ID NO:
- 1;
- (ii) the nucleotide sequence of SEQ ID NO:
- 3;
- (iii) a nucleotide sequence encoding the polypeptide of SEQ ID NO:
- 2;
- or
- (iv) a nucleotide sequence encoding the polypeptide of SEQ ID NO:
- 4.
18 more elements
A hybridoma that produces a monoclonal antibody that binds:
- (a) an isolated polypeptide comprising:
- (i) the amino acid sequence of SEQ ID NO:
- 2;
- (ii) the amino acid sequence of SEQ ID NO:
- 4;
- (iii) the amino acid sequence of SEQ ID NO:
- 2, further comprising an amino-terminal methionine;
- or
- (iv) the amino acid sequence of SEQ ID NO:
- 4, further comprising an amino-terminal methionine;
- or
- (b) an isolated polypeptide comprising an amino acid sequence that is encoded by:
- (i) the nucleotide sequence of SEQ ID NO:
- 1;
- (ii) the nucleotide sequence of SEQ ID NO:
- 3;
- (iii) a nucleotide sequence encoding the polypeptide of SEQ ID NO:
- 2;
- or
- (iv) a nucleotide sequence encoding the polypeptide of SEQ ID NO:
- 4.
18 more elements
Dependencies are inferred from the claim text.