Methods and compositions for modulating tumor cell activity
AssigneeNational Research Council of Canada
InventorsMaureen D. O'Connor-McCourt, Christiane Cantin, Anne E.G. Lenferink
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Abstract
Antibodies which target clusterin, a protein involved in the epithelial-to-mesenchymal transition of carcinoma cells, are identified and characterized. The antibodies may be used to modulate tumour cell activity through binding the clusterin.
Claims51
1-6. (canceled)
A method for modulating activity of carcinoma cells in a subject having a carcinoma by inhibiting epithelial-to-mesenchymal transitions in the carcinoma cells, the method comprising administering to the subject an antibody which specifically binds a site in the amino acid sequence VEVSRKNPKFMETVAEKALQEYR (SEQ ID NO.:
- 5) of human clusterin.
(canceled)
(canceled)
13-30. (canceled)
A method for reducing metastasis of carcinoma cells or late-stage tumor progression of carcinoma, the method comprising administering an antibody to a subject having carcinoma, wherein the antibody specifically binds to clusterin.
A method for treating metastatic carcinoma, the method comprising administering an antibody to a subject having metastatic carcinoma, wherein the antibody specifically binds to clusterin.
Dependencies are inferred from the claim text.